Euthyroid sick syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Euthyroid sick syndrome can be caused by any serious illness which leads to increased level of cytokines, decreased level of leptin, hyper-metabolism, iodine containing contrast medium, decreased protein synthesis and decreased level of thyroid-binding globulin. The conditions include *sepsis,malignancy, Trauma, surgery, burns, bone marrow transplantation, metabolic disorders, and other Inflammatory conditions

Causes

Euthyroid sick syndrome can be caused by any serious illness which leads to increased level of cytokines, decreased level of leptin, hyper-metabolism, iodine containing contrast medium, decreased protein synthesis and decreased level of thyroid-binding globulin. The conditions include:[1][2]


  • The following table summarize the effect of various drugs on thyroid hormones level.
↓ Hormone secretion ↓ T4 ↓ TSH ↓ 5' monodeiodinase ↑ Breakdown of

thyroid hormones

Thyroid binding globulin
Increased Decreased
  • Lithium
  • Amiodarone
  • Aluminum hydroxide
  • Ferrous sulphate
  • Sucralfate
  • Dopamine
  • Octreotide
  • Glucocorticoids
  • Propylthiouracil
  • Amiodarone
  • Propranolol (high dose)
  • Phenobarbital
  • Rifampin
  • Phenytoin
  • Carbamazepine
  • Estrogens
  • Tamoxifen
  • Fluorouracil
  • Methadone
  • Heroin
  • Androgens
  • Anabolic steroids
  • Glucocorticoids
  • Furosemide
  • Mefenamic acid
  • Salicylates

Causes

Common Causes

[Disease name] may be caused by:

  • [cause1]
  • [cause2]
  • [cause3]
  • [Disease name] is caused by an infection with [pathogen name].
  • [Pathogen name] is caused by [pathogen name].

Less Common Causes

Less common causes of disease name include:

  • [cause1]
  • [cause2]
  • [cause3]

Genetic Causes

  • [Disease name] is caused by a mutation in the [gene name] gene.

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

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3

References

  1. Silva MH, Araujo MC, Diniz EM, Ceccon ME, Carvalho WB (2015). "Nonthyroidal illnesses syndrome in full-term newborns with sepsis". Arch Endocrinol Metab. 59 (6): 528–34. doi:10.1590/2359-3997000000111. PMID 26677087.
  2. Frączek MM, Gackowski A, Przybylik-Mazurek E, Nessler J (2016). "[The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure]". Pol. Merkur. Lekarski (in Polish). 40 (240): 380–3. PMID 27403906.

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