Glucagonoma laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2] Mohammed Abdelwahed M.D[3]
Overview
Laboratory findings consistent with the diagnosis of glucagonoma include a serum glucagon concentration of 1000 pg/ml or greater.[1][2]
Laboratory Findings
Serum glucagon[1]
- Normal glucagon level is less than 50 pg/mL.
- Increased plasma glucagon levels (>500 pg/mL).[3]
- Concentrations above 1000 pg/mL are diagnostic of glucagonoma.[4]
- Some conditions can increase glucagon level to a level less than 500 pg/mL such as fasting and hypoglycemia.[3]
- Some symptomatic glucagonomas are associated with normal glucagon serum level. So, a serum glucagon concentration below 500 pg/mL does not exclude a glucagonoma.[4]
- Blood tests may also reveal low concentrations of amino acids, zinc, and essential fatty acids.
- A CBC to diagnose anemia
References
- ↑ 1.0 1.1 Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS (2004). "Clinical experience in diagnosis and treatment of glucagonoma syndrome". Hepatobiliary Pancreat Dis Int. 3 (3): 473–5. PMID 15313692.
- ↑ Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. Accessed on October 15,2015
- ↑ 3.0 3.1 Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV (1996). "The glucagonoma syndrome. Clinical and pathologic features in 21 patients". Medicine (Baltimore). 75 (2): 53–63. PMID 8606627.
- ↑ 4.0 4.1 Kindmark H, Sundin A, Granberg D, Dunder K, Skogseid B, Janson ET; et al. (2007). "Endocrine pancreatic tumors with glucagon hypersecretion: a retrospective study of 23 cases during 20 years". Med Oncol. 24 (3): 330–7. PMID 17873310.