Sheehan's syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

  • Sheehan syndrome, if left untreated lead to mitral regurgitation, pericardial effusion and diminished LVM.[1]
  • Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
  • Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

  • Sheehan syndrome usually results in anterior pituitary shrinkage within 20 days followed by disappearance of pituitary tissue in 6-8 week resulting in hypopituitarism and empty sella syndrome.
  • The symptoms of Sheehan's syndrome can develop during immediate post-puerperal period to years after delivery.
  • If left untreated,lead to mitral regurgitation, pericardial effusion and diminished LVM, adrenal crisis, pituitay hypopituitarism and empty sella syndrome.

Complications

  • Common complications of [disease name] include:
    • Adrenal crisis
    • Hypotension
    • Hypothyroidism
    • Menstrual irregularities
    • Empty sella syndrome

Prognosis

  • Prognosis is generally good, and results in reversal of symptoms once respective hormones are being replaced.

References

  1. Laway BA, Ramzan M, Allai MS, Wani AI, Misgar RA (2016). "CARDIAC STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN FEMALES WITH UNTREATED HYPOPITUITARISM DUE TO SHEEHAN SYNDROME: RESPONSE TO HORMONE REPLACEMENT THERAPY". Endocr Pract. 22 (9): 1096–103. doi:10.4158/EP161262.OR. PMID 27359291.

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