Riedel's thyroiditis other diagnostic studies

Jump to navigation Jump to search

Riedel's thyroiditis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Riedel's thyroiditis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Riedel's thyroiditis other diagnostic studies On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Riedel's thyroiditis other diagnostic studies

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Riedel's thyroiditis other diagnostic studies

CDC on Riedel's thyroiditis other diagnostic studies

Riedel's thyroiditis other diagnostic studies in the news

Blogs on Riedel's thyroiditis other diagnostic studies

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Riedel's thyroiditis other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Other diagnostic studies for Riedel's thyroiditis include pathological analysis, which demonstrates inflammatory cells infiltration, fibrosis with hyalinization, and extension of fibrosis outside the capsule, and immunohistochemical analysis, which demonstrates the predominance of T lymphocytes, strong positive stain to thyroglobulin, the presence of CD8+, CD4+ and plasma cells.

Other Diagnostic Studies

  • Other diagnostic studies for Riedel's thyroiditis include pathological and Immunohistochemical analysis.

Gross pathology

Gross pathology findings include:

  • Pale thyroid mass
  • No discernable tissue planes

Microscopic pathology

Microscopic pathology findings include:[1][2][3][4]

  • Inflammatory cells infiltration
  • Absence of giant cells, lymphoid follicles, oncocytes, or granulomas
  • Fibrosis with hyalinization
  • Extension of fibrosis outside the capsule
  • Infiltration of plasma cells and lymphocytes in venular walls


Immunohistochemical analysis

The immunohistochemical study in Riedel's thyroiditis is helpful to identify the inflammatory population of this form of thyroiditis. The findings include:[5][6][7][8]

  • Predominance of T lymphocytes
  • Presence of CD8+, CD4+ and plasma cells
  • Presence of granulocytes and monocytes
  • Strong positive stain to thyroglobulin

Fine needle aspiration cytology

Fine needle aspiration cytology can lead to the misleading diagnosis due to fibrosis in Riedel thyroiditis. In most of the cases, it has no diagnostic value due to acellular or paucicellular smears.[9]

References

  1. BARTHOLOMEW LG, CAIN JC, WOOLNER LB, UTZ DC, FERRIS DO (1963). "Sclerosing cholangitis: its possible association with Riedel's struma and fibrous retroperitonitis. Report of two cases". N. Engl. J. Med. 269: 8–12. doi:10.1056/NEJM196307042690102. PMID 13969693.
  2. Rao CR, Ferguson GC, Kyle VN (1973). "Retroperitoneal fibrosis associated with Riedel's struma". Can Med Assoc J. 108 (8): 1019–21. PMC 1941367. PMID 4699273.
  3. Nazarian A, Pezzella L, Tseng A, Baldassarri S, Zurakowski D, Evans CH, Snyder BD (2010). "Application of structural rigidity analysis to assess fidelity of healed fractures in rat femurs with critical defects". Calcif. Tissue Int. 86 (5): 397–403. doi:10.1007/s00223-010-9353-4. PMC 4405879. PMID 20354683.
  4. Rabinovitch A, Pukel C, Baquerizo H (1988). "Interleukin-1 inhibits glucose-modulated insulin and glucagon secretion in rat islet monolayer cultures". Endocrinology. 122 (6): 2393–8. doi:10.1210/endo-122-6-2393. PMID 2453340.
  5. "Redirecting".
  6. Schwaegerle SM, Bauer TW, Esselstyn CB (1988). "Riedel's thyroiditis". Am. J. Clin. Pathol. 90 (6): 715–22. PMID 3057862.
  7. Weetman AP, McGregor AM (1994). "Autoimmune thyroid disease: further developments in our understanding". Endocr. Rev. 15 (6): 788–830. doi:10.1210/edrv-15-6-788. PMID 7705281.
  8. Papi G, Corrado S, Carapezzi C, De Gaetani C, Carani C (2003). "Riedel's thyroiditis and fibrous variant of Hashimoto's thyroiditis: a clinicopathological and immunohistochemical study". J. Endocrinol. Invest. 26 (5): 444–9. doi:10.1007/BF03345200. PMID 12906372.
  9. "Riedel's Thyroiditis in Multifocal Fibrosclerosis: CT and MR Imaging Findings | American Journal of Neuroradiology".

Template:WH Template:WS