Sheehan's syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

  • An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
  • Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
  • [Test] is usually normal among patients with [disease name].
  • Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

  • There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

  • Laboratory findings consistent with the diagnosis of Sheehan syndrome include:
    • Hyponatremia[1][2][3]
    • Hypokalemia
    • Hypocalcemia
    • Hypomagnesemia
    • Hypophosphatemia
    • Anemia[3]
    • Pancytopenia[4]
    • Eosinophilia[5]
    • Hypoalbuminemia
    • Low fasting plasma glucose
    • Elevated serum SGOT
    • Thrombocytopenia
    • Decreased levels of anterior pituitary hormones in blood.
  • Most sensitive test is inadequate prolactin and gonadotropin responses to stimulation.
  • Baseline and stimulated anterior pituitary hormone level measurements.

References

  1. Shoji M, Kimura T, Ota K, Ohta M, Sato K, Yamamoto T, Funyu T, Mori T, Tateyama M, Abe K (1996). "Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia". Intern. Med. 35 (5): 427–31. PMID 8797063.
  2. Putterman C, Almog Y, Caraco Y, Gross DJ, Ben-Chetrit E (1991). "Inappropriate secretion of antidiuretic hormone in Sheehan's syndrome: a rare cause of postpartum hyponatremia". Am. J. Obstet. Gynecol. 165 (5 Pt 1): 1330–3. PMID 1957856.
  3. 3.0 3.1 Anfuso S, Patrelli TS, Soncini E, Chiodera P, Fadda GM, Nardelli GB (2009). "A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia". Acta Biomed. 80 (1): 73–6. PMID 19705625.
  4. Laway BA, Bhat JR, Mir SA, Khan RS, Lone MI, Zargar AH (2010). "Sheehan's syndrome with pancytopenia--complete recovery after hormone replacement (case series with review)". Ann. Hematol. 89 (3): 305–8. doi:10.1007/s00277-009-0804-9. PMID 19697029.
  5. Ratarasarn C, Rajatanavin R, Himathongkam T (1989). "Salient clinical features of Sheehan's syndrome". J Med Assoc Thai. 72 (1): 41–7. PMID 2723566.

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