Sheehan's syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]

Overview

Common causes of Sheehan's syndrome include massive hemorrhage, hypotension during pregnancy, vascular compression, and vascular occlusion(thrombosis, DIC). Less common causes include vascular insufficiency due to CABG in older patients and snake bites(Russell's viper bites).

Causes

Life-threatening Causes

• PPH

Common Causes

Sheehan's syndrome may be caused by:

• Massive hemorrhage during and after pregnancy
• Vascular compression due to enlarged pituitary gland or small and rigid sella
• Vascular occlusion(thrombosis, DIC)

Less Common Causes

Less common causes of Sheehan's syndrome include:

• Vascular insufficiency due to CABG in older patients
• Snake bites(Russell's viper bites).

Genetic Causes

• Sheehan's syndrome is not associated with any genetic mutation.

Causes by Organ System

Cardiovascular	Hypotension , vascular compression, hemorrhage
Chemical/Poisoning	Snake bites
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	No underlying causes
Hematologic	Thrombosis, DIC
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	PPH, Traumatic birth delivery
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	Autoimmunity
Sexual	No underlying causes
Trauma	Traumatic delivery
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in alphabetical order

• Autoimmunity
• DIC
• Postpartum hemorrhage
• Snake bites
• Small and rigid sella
• Thrombosis
• Traumatic birth delivery