Hemolytic anemia historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
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Overview
Historical Perspective
In 1891, Paul Ehrlich discovered that methylene blue had activity against malaria.[1]
In 1920, it was noted that primaquine was an effective anti-malarial medication.
In 1953, there was large-scale use of primaquine for troops in the army in order to protect against malaria, and it was soon noted that soldiers developed abdominal discomfort, anemia, and jaundice.[1]
In 1956, Carson's group showed that people who experienced hemolysis from primaquine had decreased level of G6PD.[1]
In 1962, Alving's group showed that acute hemolytic anemia could be triggered by primaquine.[1]