Toxic Adenoma overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
A toxic adenoma is a benign tumor consisting of thyroid follicular cells, which produce excessive amounts of T 3 and/or T 4. In toxic adenoma, the excessive thyroid hormone autonomously produced can suppress the function of remaining thyroid tissue. Thus thyroid hormone production is no longer controlled by the hypothalamic-hypophyseal-thyroid axis, leading to thyroid hormone excess and the resulting clinical symptoms, signs, and potential complications.
Historical Perspective
In 1840, Adolph von Basedow from Germany was the first to coin the term toxic adenoma. In 1913, Henry Plummer was the first to give a detailed description of toxic adenoma.