Adrenocortical carcinoma history and symptoms
|
Adrenocortical carcinoma Microchapters |
|
Differentiating Adrenocortical carcinoma from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Study |
|
Adrenocortical carcinoma history and symptoms On the Web |
|
American Roentgen Ray Society Images of Adrenocortical carcinoma history and symptoms |
|
Risk calculators and risk factors for Adrenocortical carcinoma history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]
Overview
Symptoms of adrenocortical carcinoma include symptoms of androgen, glucocorticoid, mineralocorticoid, or estrogen excess.
Common Symptoms
60 percent of adrenocortical carcinoma (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.[1]
- Forty-five percent of ACCs show symptoms of Cushing's syndrome alone
- Twenty-five percent present with mixed overproduction of both glucocorticoids and androgens.[2]
- Ten percent present with virilization alone
1- Symptoms of glucocorticoid excess include:
2- Symptoms of androgen excess symptoms (most readily noted among womens) include:
- Excess facial and body hair
- Acne
- Deepening of the voice
- Coarsening of facial features
- Cessation of menstruation
3- Symptoms of mineralcorticoid excess include:
4- Symptoms of estrogen excess (most readily noted in mens) include:
- Gynecomastia
- Decreased libido
- Impotence
5- symptoms of catecholamines excess has been reported in adrenocortical cancers:[3]
6- Other symptoms may include:[4]
- Abdominal lump
- Abdominal or back pain
- Abdominal fullness
Children usually present with virilization (84%), while isolated glucocorticoid excess is much less common (6%).[5]
References
- ↑ Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update". J Clin Endocrinol Metab. 91 (6): 2027–37. doi:10.1210/jc.2005-2639. PMID 16551738.
- ↑ Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA; et al. (2000). "Adrenocortical carcinoma: clinical and laboratory observations". Cancer. 88 (4): 711–36. PMID 10679640.
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1
- ↑ Stewart JN, Flageole H, Kavan P (2004). "A surgical approach to adrenocortical tumors in children: the mainstay of treatment". J Pediatr Surg. 39 (5): 759–63. PMID 15137014.