Hypoparathyroidism laboratory findings

Hypoparathyroidism Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Hypoparathyroidism from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Hypoparathyroidism laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Hypoparathyroidism laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Hypoparathyroidism laboratory findings
CDC on Hypoparathyroidism laboratory findings
Hypoparathyroidism laboratory findings in the news
Blogs on Hypoparathyroidism laboratory findings
Directions to Hospitals Treating Hypoparathyroidism
Risk calculators and risk factors for Hypoparathyroidism laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

Diagnosis of hypoparathyroidism is made by measurement of serum calcium (total and ionized), serum albumin (for correction), phosphate, intact Parathyroid hormone (PTH), and 25-hydroxyvitamin D (25[OH] vitamin D) levels. PTH degrades rapidly at ambient temperatures and the blood sample therefore has to be transported to the laboratory on ice.

If necessary, measuring cAMP (cyclic AMP) in the urine after an intravenous dose of PTH can help in the distinction between hypoparathyroidism and other causes.

Calculation of corrected total calcium

Corrected total calcium = measured total calcium + 0.8 (4.0 − serum albumin)

In this formula, serum calcium is measured in mg/dL and serum albumin is measured in gm/dL.

• Normal or inappropriately low intact parathyroid hormone level with subnormal serum albumin corrected total or ionized calcium values in a patient is diagnostic of hypoparathyroidism. Hypomagnesemia should be rule out before.

Laboratory Findings

• There are no diagnostic laboratory findings associated with [disease name].

OR

• An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
• [Test] is usually normal among patients with [disease name].
• Laboratory findings consistent with the diagnosis of hypoparathyroidism include:
  • Low parathyroid hormone
  • Low serum calcium concentration

• Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].