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  • The screening for toxic multinodular goiter includes as follows:[1][2][3][4]
  • Toxic multinodular goiter is diagnosed with a physical examination which shows nodules in the throat and rapid heart rate, among other signs such as diaphoresis, tremors.
  • Blood screening includes tests for elevated T3 and T4 hormone levels that indicate hyperthyroidism.
  • TSH assays are the best initial screening tool for hyperthyroidism. Patients with TNG will have suppressed TSH levels.
  • Low levels of thyroid-stimulating hormone (TSH) are suggestive of hyperthyroidism
  • An isolated increase in T4 is observed in iodine-induced hyperthyroidism or patients taking propranolol, corticosteroids, radiocontrast agents, amiodarone.
  • 5-46% of patients with toxic nodules have normal free T4 levels with an elevated T3, this is called T3 toxicosis.
  • overactive nodules are found on ultrasound scans of the thyroid to create images of the thyroid, which can reveal the conjunction with a special radioactive iodine test that involves swallowing a pill prior to special scans.
  • The normal range for total T3 and T4 levels may vary for each and every individual; especially in case of people with nonthyroidal illness with decreased T3 levels.
  1. "Toxic multinodular goitre. Personal case histories and literature review. - PubMed - NCBI".
  2. "Hyperfunctioning thyroid nodules. - PubMed - NCBI".
  3. "Relationship between metabolic syndrome and multinodular non-toxic goiter in an inpatient population from a geographic area with moderate iodine de... - PubMed - NCBI".
  4. "Thyroid cancer in toxic and non-toxic multinodular goiter. - PubMed - NCBI".