Myxedema coma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

History

• History of thyroid disease
• History of radioiodine therapy or thyroidectomy,
• Thyroid hormone therapy that was inappropriately discontinued

Symptoms

The function of all organ systems and various metabolic pathways are compromised in hypothyroidism. The cardinal symptoms of myxedema coma are the sensory impairment and hypothermia. The accumulation in the interstitial tissue of mucopolysaccharides and water leads to myxedema that compromises large part of the tissues. Symptoms of myxedema coma can be summarized in the following table:

Organ system involved	Manifestations
CNS	Lethargy Poor memory Cognitive dysfunction Depression Psychosis Hypothermia Focal or generalized seizures
Cardiovascular	SOB Chest pain
Pulmonary
Gastro-intestinal	Anorexia Nausea Abdominal pain Constipation
Renal and electrolyte	Bladder atony with urinary retention
Systemic	Presence of normal temperature in myxedema indicates presence of infection