Sandbox MKK
Common causes[edit | edit source][1]
- Helicobacter pylori(60% gastric and 50-75% duodenal ulcers ).
- Drugs-NSAIDs including aspirin{[2]
Less common causes of peptic ulcer disease
- Hormonal or mediator-induced including secondary acid hypersecretory states
- Gastrinomas
- systemic mastocytosis
- carcinoid syndrome
- myeloproliferative disorder
- antral g - cell hyperfunction.
- Post-surgical -Antral exclusion and post gastric bypass surgery.
- Tumors-cancers and lymphoma
- Cameron ulcer (gastric ulcer where a hiatus hernia passes
through the diaphragmatic hiatus)
- True idiopathic ulcer.
Rare causes of peptic ulcer disease [1]
- Crohn’s disease of the stomach or duodenum
- Eosinophilic gastroduodenitis
- Systemic mastocytosis
- Radiation damage
- Viral infections (eg, cytomegalovirus or herpes simplex
infection, in particular in immunocompromised patients)
- Colonisation of stomach with H heilmanii
- Severe systemic disease
Genetic causes -[3]
- Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.
Causes by organ system[edit | edit source] To obtain the coding for the table seen below, click here. You need to copy the table content from the edit box, and paste it into the edit box. You can then list the causes by organ system. List the causes, separated by a comma under the appropriate category where it says "No underlying causes". Erase "No underlying causes" if you are listing causes in that category. For an example of the causes by organ system table in a causes microchapter, click here. Cardiovascular No underlying causes Chemical/Poisoning No underlying causes Dental No underlying causes Dermatologic No underlying causes Drug Side Effect No underlying causes Ear Nose Throat No underlying causes Endocrine No underlying causes Environmental No underlying causes Gastroenterologic No underlying causes Genetic No underlying causes Hematologic No underlying causes Iatrogenic No underlying causes Infectious Disease No underlying causes Musculoskeletal/Orthopedic No underlying causes Neurologic No underlying causes Nutritional/Metabolic No underlying causes Obstetric/Gynecologic No underlying causes Oncologic No underlying causes Ophthalmologic No underlying causes Overdose/Toxicity No underlying causes Psychiatric No underlying causes Pulmonary No underlying causes Renal/Electrolyte No underlying causes Rheumatology/Immunology/Allergy No underlying causes Sexual No underlying causes Trauma No underlying causes Urologic No underlying causes Miscellaneous No underlying causes Causes in alphabetical order[edit | edit source] List the causes of the disease in alphabetical order.
Cause 1 Cause 2 Cause 3 Cause 4 Cause 5 Cause 6 Cause 7 Cause 8 Cause 9 Cause 10
- ↑ 1.0 1.1 Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
- ↑ Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
- ↑ Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.