Pseudohypoparathyroidism differential diagnosis
Pseudohypoparathyroidism Microchapters |
Differentiating Pseudohypoparathyroidism from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
Pseudohypoparathyroidism differential diagnosis On the Web |
American Roentgen Ray Society Images of Pseudohypoparathyroidism differential diagnosis |
Risk calculators and risk factors for Pseudohypoparathyroidism differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]
Overview
Differentiating Pseudohypoparathyroidism from other Diseases
Differential diagnosis of Pseudohypoparathyroidism | |||||||
---|---|---|---|---|---|---|---|
Disorders | Mechanism | Laboratory findings | |||||
Serum PTH | Serum Calcium | Serum Phosphate | Other findings | ||||
Pseudohypoparathyroidism [1][2][3] | Type 1a |
|
↑ | ↓ | ↑ |
| |
Type 1b |
|
↑ | ↓ | ↑ |
| ||
Type 1c |
|
↑ | ↓ | ↑ |
| ||
Type 2 |
|
↑ | ↓ | ↑ |
| ||
Pseudopseudohypoparathyroidism |
|
Normal | Normal | Normal | -- | ||
Hypoparathyroidism |
|
↓ | ↓ | ↑ |
| ||
Hypomagnesemia[4][5] |
|
Inappropriately ↓ | Normal/↓ | -- |
| ||
Acrodysostosis | Acrodysostosis type 1 |
|
↑ | ↓ | ↑ | Multiple hormone resistance | |
Acrodysostosis type 2 |
|
↑ | ↓ | ↑ | Multiple hormone resistance | ||
Blomstrand chondrodysplasia |
|
↑ | ↓ | ↑ | ↓ Urinary Phosphate, ↑ Urinary cAMP | ||
Hyperparathyroidism | Primary hyperparathyroidism |
|
↑ | ↑ | ↓/Normal | Normal/↑ calcitriol | |
Secondary hyperparathyroidism |
|
↑ | ↓/Normal | ↑ | -- | ||
Tertiary hyperparathyroidism |
|
↑ | ↑ | ↑ |
-- |
References
- ↑ Levine MA (2012). "An update on the clinical and molecular characteristics of pseudohypoparathyroidism". Curr Opin Endocrinol Diabetes Obes. 19 (6): 443–51. doi:10.1097/MED.0b013e32835a255c. PMC 3679535. PMID 23076042.
- ↑ Mantovani G (2011). "Clinical review: Pseudohypoparathyroidism: diagnosis and treatment". J. Clin. Endocrinol. Metab. 96 (10): 3020–30. doi:10.1210/jc.2011-1048. PMID 21816789.
- ↑ Lee S, Mannstadt M, Guo J, Kim SM, Yi HS, Khatri A, Dean T, Okazaki M, Gardella TJ, Jüppner H (2015). "A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism". J. Bone Miner. Res. 30 (10): 1803–13. doi:10.1002/jbmr.2532. PMC 4580526. PMID 25891861.
- ↑ Jahnen-Dechent W, Ketteler M (2012). "Magnesium basics". Clin Kidney J. 5 (Suppl 1): i3–i14. doi:10.1093/ndtplus/sfr163. PMC 4455825. PMID 26069819.
- ↑ Freitag JJ, Martin KJ, Conrades MB, Bellorin-Font E, Teitelbaum S, Klahr S, Slatopolsky E (1979). "Evidence for skeletal resistance to parathyroid hormone in magnesium deficiency. Studies in isolated perfused bone". J. Clin. Invest. 64 (5): 1238–44. doi:10.1172/JCI109578. PMC 371269. PMID 227929.