Marburg hemorrhagic fever pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief:
Overview
Pathophysiology
Pathogen
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- Marburg virus is the causative agent of Marburg haemorrhagic fever (MHF). Marburg and Ebola viruses are the two members of the Filoviridae family (filovirus). Though caused by different viruses, the two diseases are clinically similar.
- The viral structure is typical of filoviruses, with long threadlike particles which have a consistent diameter but vary greatly in length from an average of 800 nanometers up to 14,000 nm. Peak infectious activity is at approximately 790 nm.
- Virions contain seven known structural proteins. Four proteins form the nucelocapsid of the Marburg virus: NP, VP35, VP30, and L.[2] While nearly identical to Ebola virus in structure, Marburg virus is antigenically distinct from Ebola virus.
- Marburg virus was the first filovirus to be identified.
Transmission
- Initial human infection results from prolonged exposure to mines or caves inhabited by Rousettus bat colonies. The reservoir host of Marburg virus is the African fruit bat, Rousettus aegyptiacus. Marburg virus can infect primates (including humans) and may cause serious disease with high mortality.[3]
- After the Marburg virus initially transfers from animal host to human, mode of transmission is usually human-to-human and results from direct contact with bodily fluids of infected persons(blood, secretions) other contact fomites contaminated with infectious blood and tissues.[4]
- Transmission to health-care workers has been reported while treating Marburg patients, mainly due to incorrect or inadequate use of personal protective equipment.
Pathogenesis
| Marburg virus | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dendritic cells | Adrenal Cortical cells | Hepatocytes | Macropohages | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Paralysis of cellular antiviral response | Dysregulated costimulation | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue factor | TNF-α IL-6 | TNF-α | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Endothelial cells | T lymphocytes(CD4+/CD8+ and Natural killer cells | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Coagulation dysregulation (DIC) | Increased vascular permeability | TNF-related apoptosis-inducing ligand(TRAIL) | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Liver dysfunction Inhibition of coagulation factor synthesis | Apoptosis of lymphocytes leading to lymphopenia | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Immunosupression | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Hypotension Metabolic disorder | Hemorrhagic syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Shock Multiorgan failure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
References
- ↑ "http://phil.cdc.gov/phil/details.asp". External link in
|title=(help) - ↑ Becker S, Rinne C, Hofsäss U, Klenk HD, Mühlberger E (1998). "Interactions of Marburg virus nucleocapsid proteins". Virology. 249 (2): 406–17. doi:10.1006/viro.1998.9328. PMID 9791031.
- ↑ Adjemian J, Farnon EC, Tschioko F, Wamala JF, Byaruhanga E, Bwire GS, Kansiime E, Kagirita A, Ahimbisibwe S, Katunguka F, Jeffs B, Lutwama JJ, Downing R, Tappero JW, Formenty P, Amman B, Manning C, Towner J, Nichol ST, Rollin PE (2011). "Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007". J. Infect. Dis. 204 Suppl 3: S796–9. doi:10.1093/infdis/jir312. PMC 3203392. PMID 21987753.
- ↑ Borio L, Inglesby T, Peters CJ, Schmaljohn AL, Hughes JM, Jahrling PB; et al. (2002). "Hemorrhagic fever viruses as biological weapons: medical and public health management". JAMA. 287 (18): 2391–405. PMID 11988060.