Plummer-Vinson syndrome natural history, complications and prognosis

Plummer-Vinson syndrome Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

• The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
• The symptoms of (disease name) typically develop ___ years after exposure to ___.
• If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Complications

• Common complications of Plummer-Vinson syndrome include:
  • Hypopharyngeal cancer
  • Esophageal cancer
  • Malignant lesions of oral mucosa

Prognosis

• Depending on the extent of Plummer-Vinson syndrome at the time of diagnosis, the prognosis may vary.
• Prognosis is generally good for patients of Plummer-Vinson syndrome who receive treatment unless complicated by pharyngeal or esophageal carcinoma.
• Anemia and esophageal webs seen in PV syndrome can be rapidly reversed with iron replacement therapy and dilatation respectively.
• Studies have shown that patients of Plummer-Vinson syndrome are at a high risk of developing malignant lesions of the oral mucosa, hypopharynx, and esophagus. Therefore, untreated patients require regular surveillance and close follow up.