Esophageal stricture causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

Common causes of esophageal stricture include gastroesophageal reflux disease and caustic ingestions.

Causes

Life-threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of esophageal stricture, however complications resulting from untreated esophageal stricture is common.

Common Causes

Esophageal stricture may be caused by:^[1]

Gastroesophageal reflux disease^[2]
Caustic ingestions^[3]
Radiation therapy for thoracic or head and neck tumors^[4]
Esophageal cancer

Less Common Causes

Less common causes of esophageal stricture include:

Esophageal sclerotherapy^[5]
Eosinophilic esophagitis^[6]

Dyskeratosis congenita (DC)^[7]
Rare dermatologic diseases (eg, epidermolysis bullosa dystrophica)^[8]
Mediastinal fibrosis due to tuberclosis or idiopathic fibrosing mediastinitis^[9]
Drug-induced stricture:^[10]
- Aspirin and anti-inflammatory medications^[11]
- Tetracycline
- Doxycycline
- Clindamycin
- Bisphosphonates
- Potassium chloride
- Quinidine preparations
- Iron compounds
- Emepronium
- Alprenolol
- Pinaverium

Infectious esophagitis^[12]

Tracheoesophageal fistula repair and esophageal stricture at the anastomosis^[13]
Esophageal diverticula^[14]
Increased level of gastric acid exposure to esophageal tissue, for example:
- Systemic sclerosis^[15]
- Zollinger-Ellison syndrome^[16]
- Nasogastric tube placement^[16]
- Heller myotomy for achalasia^[17]

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	Caustic ingestion
Dental	No underlying causes
Dermatologic	Dyskeratosis congenita (DC), epidermolysis bullosa dystrophica
Drug Side Effect	Drug-induced stricture:^[10] Aspirin and anti-inflammatory medications^[11] Tetracycline Doxycycline Clindamycin Bisphosphonates Potassium chloride Quinidine preparations Iron compounds Emepronium Alprenolol Pinaverium
Ear Nose Throat	No underlying causes
Endocrine	Zollinger-Ellison syndrome,
Environmental	No underlying causes
Gastroenterologic	Gastroesophageal reflux disease, Eosinophilic esophagitis, Esophageal diverticula, Zollinger-Ellison syndrome, Systemic sclerosis
Genetic	No underlying causes
Hematologic	No underlying causes
Iatrogenic	Previous surgery on the esophagus, Radiation therapy for thoracic or head and neck tumors, Esophageal sclerotherapy,Tracheoesophageal fistula repair, Nasogastric tube placement, Heller myotomy for achalasia
Infectious Disease	Infectious esophagitis Candida Herpes simplex virus (HSV) Cytomegalovirus (CMV) Human immunodeficiency virus (HIV)
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Mediastinal fibrosis due to tuberclosis or idiopathic fibrosing mediastinitis
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	Systemic sclerosis
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

Caustic ingestions

Drug-induced stricture
Dyskeratosis congenita (DC)
Eosinophilic esophagitis
Esophageal diverticula
Esophageal sclerotherapy
Gastroesophageal reflux disease
Increased level of gastric acid exposure to esophageal tissue
Infectious esophagitis
Mediastinal fibrosis due to tuberclosis or idiopathic fibrosing mediastinitis
Radiation therapy for thoracic or head and neck tumors
Rare dermatologic diseases (eg, epidermolysis bullosa dystrophica)
Tracheoesophageal fistula repair and esophageal stricture at the anastomosis

References

↑ Csendes A, Braghetto I (1992). "Surgical management of esophageal strictures". Hepatogastroenterology. 39 (6): 502–10. PMID 1483661.
↑ Marks RD, Richter JE (1993). "Peptic strictures of the esophagus". Am. J. Gastroenterol. 88 (8): 1160–73. PMID 8338082.
↑ Wasserman RL, Ginsburg CM (1985). "Caustic substance injuries". J. Pediatr. 107 (2): 169–74. PMID 4020540.
↑ Coia LR, Myerson RJ, Tepper JE (1995). "Late effects of radiation therapy on the gastrointestinal tract". Int. J. Radiat. Oncol. Biol. Phys. 31 (5): 1213–36. doi:10.1016/0360-3016(94)00419-L. PMID 7713784.
↑ Guynn TP, Eckhauser FE, Knol JA, Raper SE, Mulholland MW, Nostrant TT, Elta GH, Barnett JL (1991). "Injection sclerotherapy-induced esophageal strictures. Risk factors and prognosis". Am Surg. 57 (9): 567–71, discussion 571–2. PMID 1928999.
↑ Furuta, Glenn T.; Ingelfinger, Julie R.; Katzka, David A. (2015). "Eosinophilic Esophagitis". New England Journal of Medicine. 373 (17): 1640–1648. doi:10.1056/NEJMra1502863. ISSN 0028-4793.
↑ Jonassaint NL, Guo N, Califano JA, Montgomery EA, Armanios M (2013). "The gastrointestinal manifestations of telomere-mediated disease". Aging Cell. 12 (2): 319–23. doi:10.1111/acel.12041. PMC 3602337. PMID 23279657.
↑ Guerra-Leal JD, Meester I, Cantu-Gonzalez JR, Ornelas-Cortinas G, Montemayor-Martinez A, Salas-Alanis JC (2016). "The Importance of Esophagography in Patients With Recessive Dystrophic Epidermolysis Bullosa". AJR Am J Roentgenol: 1–4. doi:10.2214/AJR.16.16115. PMID 27384758.
↑ Goenka MK, Gupta NM, Kochhar R, Rungta U, Vaiphei K, Nagi B, Suri S (1995). "Mediastinal fibrosis: an unusual cause of esophageal stricture". J. Clin. Gastroenterol. 20 (4): 331–3. PMID 7665827.
↑ ^10.0 ^10.1 Bonavina L, DeMeester TR, McChesney L, Schwizer W, Albertucci M, Bailey RT (1987). "Drug-induced esophageal strictures". Ann Surg. 206 (2): 173–83. PMC 1493104. PMID 3606243.
↑ ^11.0 ^11.1 Kikendall JW, Friedman AC, Oyewole MA, Fleischer D, Johnson LF (1983). "Pill-induced esophageal injury. Case reports and review of the medical literature". Dig. Dis. Sci. 28 (2): 174–82. PMID 6825537.
↑ Wilcox CM (2013). "Overview of infectious esophagitis". Gastroenterol Hepatol (N Y). 9 (8): 517–9. PMC 3980995. PMID 24719600.
↑ Lakoma A, Fallon SC, Mathur S, Kim ES (2013). "Use of Mitomycin C for Refractory Esophageal Stricture following Tracheoesophageal Fistula Repair". European J Pediatr Surg Rep. 1 (1): 24–6. doi:10.1055/s-0033-1341418. PMC 4335951. PMID 25755944.
↑ Smith, C. Daniel (2015). "Esophageal Strictures and Diverticula". Surgical Clinics of North America. 95 (3): 669–681. doi:10.1016/j.suc.2015.02.017. ISSN 0039-6109.
↑ Ebert, Ellen C. (2008). "Esophageal disease in progressive systemic sclerosis". Current Treatment Options in Gastroenterology. 11 (1): 64–69. doi:10.1007/s11938-008-0008-8. ISSN 1092-8472.
↑ ^16.0 ^16.1 Luedtke, Pia; Levine, Marc S.; Rubesin, Stephen E.; Weinstein, Donald S.; Laufer, Igor (2003). "Radiologic Diagnosis of Benign Esophageal Strictures: A Pattern Approach". RadioGraphics. 23 (4): 897–909. doi:10.1148/rg.234025717. ISSN 0271-5333.
↑ Ferguson MK (1991). "Achalasia: current evaluation and therapy". Ann. Thorac. Surg. 52 (2): 336–42. PMID 1863166.

Template:WH Template:WS

[pmid1483661-1] Csendes A, Braghetto I (1992). "Surgical management of esophageal strictures". Hepatogastroenterology. 39 (6): 502–10. PMID 1483661.

[pmid8338082-2] Marks RD, Richter JE (1993). "Peptic strictures of the esophagus". Am. J. Gastroenterol. 88 (8): 1160–73. PMID 8338082.

[pmid4020540-3] Wasserman RL, Ginsburg CM (1985). "Caustic substance injuries". J. Pediatr. 107 (2): 169–74. PMID 4020540.

[pmid7713784-4] Coia LR, Myerson RJ, Tepper JE (1995). "Late effects of radiation therapy on the gastrointestinal tract". Int. J. Radiat. Oncol. Biol. Phys. 31 (5): 1213–36. doi:10.1016/0360-3016(94)00419-L. PMID 7713784.

[pmid1928999-5] Guynn TP, Eckhauser FE, Knol JA, Raper SE, Mulholland MW, Nostrant TT, Elta GH, Barnett JL (1991). "Injection sclerotherapy-induced esophageal strictures. Risk factors and prognosis". Am Surg. 57 (9): 567–71, discussion 571–2. PMID 1928999.

[FurutaIngelfinger2015-6] Furuta, Glenn T.; Ingelfinger, Julie R.; Katzka, David A. (2015). "Eosinophilic Esophagitis". New England Journal of Medicine. 373 (17): 1640–1648. doi:10.1056/NEJMra1502863. ISSN 0028-4793.

[pmid23279657-7] Jonassaint NL, Guo N, Califano JA, Montgomery EA, Armanios M (2013). "The gastrointestinal manifestations of telomere-mediated disease". Aging Cell. 12 (2): 319–23. doi:10.1111/acel.12041. PMC 3602337. PMID 23279657.

[pmid27384758-8] Guerra-Leal JD, Meester I, Cantu-Gonzalez JR, Ornelas-Cortinas G, Montemayor-Martinez A, Salas-Alanis JC (2016). "The Importance of Esophagography in Patients With Recessive Dystrophic Epidermolysis Bullosa". AJR Am J Roentgenol: 1–4. doi:10.2214/AJR.16.16115. PMID 27384758.

[pmid7665827-9] Goenka MK, Gupta NM, Kochhar R, Rungta U, Vaiphei K, Nagi B, Suri S (1995). "Mediastinal fibrosis: an unusual cause of esophageal stricture". J. Clin. Gastroenterol. 20 (4): 331–3. PMID 7665827.

[pmid3606243-10] 10.0 ^10.1 Bonavina L, DeMeester TR, McChesney L, Schwizer W, Albertucci M, Bailey RT (1987). "Drug-induced esophageal strictures". Ann Surg. 206 (2): 173–83. PMC 1493104. PMID 3606243.

[pmid6825537-11] 11.0 ^11.1 Kikendall JW, Friedman AC, Oyewole MA, Fleischer D, Johnson LF (1983). "Pill-induced esophageal injury. Case reports and review of the medical literature". Dig. Dis. Sci. 28 (2): 174–82. PMID 6825537.

[pmid247196002-12] Wilcox CM (2013). "Overview of infectious esophagitis". Gastroenterol Hepatol (N Y). 9 (8): 517–9. PMC 3980995. PMID 24719600.

[pmid25755944-13] Lakoma A, Fallon SC, Mathur S, Kim ES (2013). "Use of Mitomycin C for Refractory Esophageal Stricture following Tracheoesophageal Fistula Repair". European J Pediatr Surg Rep. 1 (1): 24–6. doi:10.1055/s-0033-1341418. PMC 4335951. PMID 25755944.

[Smith2015-14] Smith, C. Daniel (2015). "Esophageal Strictures and Diverticula". Surgical Clinics of North America. 95 (3): 669–681. doi:10.1016/j.suc.2015.02.017. ISSN 0039-6109.

[Ebert2008-15] Ebert, Ellen C. (2008). "Esophageal disease in progressive systemic sclerosis". Current Treatment Options in Gastroenterology. 11 (1): 64–69. doi:10.1007/s11938-008-0008-8. ISSN 1092-8472.

[LuedtkeLevine2003-16] 16.0 ^16.1 Luedtke, Pia; Levine, Marc S.; Rubesin, Stephen E.; Weinstein, Donald S.; Laufer, Igor (2003). "Radiologic Diagnosis of Benign Esophageal Strictures: A Pattern Approach". RadioGraphics. 23 (4): 897–909. doi:10.1148/rg.234025717. ISSN 0271-5333.

[pmid1863166-17] Ferguson MK (1991). "Achalasia: current evaluation and therapy". Ann. Thorac. Surg. 52 (2): 336–42. PMID 1863166.

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