Plummer-Vinson syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]

Overview

Causes

The cause of Plummer-Vinson syndrome is unknown; however, iron deficiency anemia, genetic factors and nutritional deficiencies may play a role. Iron deficiency anemia is the most widely regarded cause of Plummer-Vinson syndrome and can be due to:

Increased Iron Requirement

Physiological

Pathological

Blood Loss

Inadequate Iron Absorption


celiac disease tropical sprue Crohn’s disease Whipple disease Kwashiorkor disease Alcoholism

Less common causes

Hereditary hemorrhagic telangiectasia: recurrent hemorrhage

Intravascular hemolysis: for example, paroxysmal nocturnal hemoglobinuria.

Iatrogenic causes such as frequent blood draws, particularly in hospitalized patients

inadequate diet in children (excessive consumption of whole cow's milk)

References