Whipple's disease other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of [ Whipple's disease] include PAS positive inclusions in macrophages of lamina propria.
Other diagnostic studies for [Whipple's disease] include electron microscopy which demostrate bacteria , immunofluoroscent assay to detect antibodies against T whippleii and [PCR], which demonstrates 16S rRNA gene of T. Whipplei.
Other Diagnostic Studies
- Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of [ Whipple's disease] include:
- PAS positive inclusions in macrophages of lamina propria.
- All the organs affected by disease may demostrate PAS-positive macrophages like heart, lungs, CNS , eyes, liver, spleen, joints, and bone marrow.
- Other diagnostic studies for [Whipple's disease] which confirm the diagnosis include:
- [Electron Microscopy], which demonstrates:
- typical trilamellar membrane of T. Whippleii.
- gram positive cell wall structure
- [Electron Microscopy], which demonstrates:
- PCR of affected tissue which demonstrates:
- 16S rRNA gene of T. Whipplei
- Immunofluoroscent assay of serum of patients with Whipple's disease which demonstrates:
- Antibodies against T. Whippleii in patients' serum.