Autoimmune pancreatitis classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There is no established system for the classification of [disease name].
OR
[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].
OR
[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3]. [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].
OR
Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
OR
If the staging system involves specific and characteristic findings and features: According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
OR
The staging of [malignancy name] is based on the [staging system].
OR
There is no established system for the staging of [malignancy name].
Classification
- Autoimmune pancreatitis may be classified into two types.
- Type 1 AIP
- Type 2 AIP or idiopathic duct-centric pancreatitis
Type 1 AIP:
- Type 1 AIP meets the HISORt criteria.[1][2]
- Type 1 AIP involves pancreas as one part of a systemic IgG4-positive disease.
- Type 1 patients have high relapse rates when compared to type 2 patients.[3]
- Type 1 patients are usually older on presentation.
- Type 1 patients have higher prevalence of increased IgG4 levels.
- Type 1 patients have greater extrapancreatic organ involvement compared to Type 2 AIP patients.
| Criteria | |
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| (H) | Histology suggestive of autoimmine pancreatitis |
| (I) | Pancreatic imaging suggestive of autoimmine pancreatitis |
| (S) | Serology (IgG4 ≥2 times the upper limit of normal) |
| (O) | Other organ involvement
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| (Rt) | Response to steroid treatment |
Type 2 AIP or Idiopathic duct-centric pancreatitis:
- Type 2 consists of granulocytic lesions.
- Type 2 does not involve IgG4-positive cells.
- Type 2 has no systemic involvement.
- Type 2 AIP is usually associated with inflammatory bowel disease.
References
- ↑ Chari ST, Takahashi N, Levy MJ, Smyrk TC, Clain JE, Pearson RK, Petersen BT, Topazian MA, Vege SS (2009). "A diagnostic strategy to distinguish autoimmune pancreatitis from pancreatic cancer". Clin. Gastroenterol. Hepatol. 7 (10): 1097–103. doi:10.1016/j.cgh.2009.04.020. PMID 19410017.
- ↑ Chari ST, Smyrk TC, Levy MJ, Topazian MD, Takahashi N, Zhang L, Clain JE, Pearson RK, Petersen BT, Vege SS, Farnell MB (2006). "Diagnosis of autoimmune pancreatitis: the Mayo Clinic experience". Clin. Gastroenterol. Hepatol. 4 (8): 1010–6, quiz 934. doi:10.1016/j.cgh.2006.05.017. PMID 16843735.
- ↑ Sah RP, Chari ST, Pannala R, Sugumar A, Clain JE, Levy MJ, Pearson RK, Smyrk TC, Petersen BT, Topazian MD, Takahashi N, Farnell MB, Vege SS (2010). "Differences in clinical profile and relapse rate of type 1 versus type 2 autoimmune pancreatitis". Gastroenterology. 139 (1): 140–8, quiz e12–3. doi:10.1053/j.gastro.2010.03.054. PMID 20353791.