Epithelioid sarcoma other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Other diagnostic studies for epithelioid sarcoma include genetic testing and immunohistochemistry.

Genetic Testing

• Loss of INI1 (also known as hSNF5 and SMARCB1),which is a member of SWI/SNF multi-subunit chromatin remodeling complex located on the long arm of chromosome 22 (22q11.2), has been used as a diagnostic modality of epithelioid sarcoma.

Immunohistochemistry

• Immunohistochemical staining of INI1 is available and can be used for the diagnosis of epithelioid sarcoma.
• Vimentin reactivity
• Pankeratin AE1/AE3 and epithelial membrane antigen
• Negative S100