Neoplastic meningitis causes
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Neoplastic meningitis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Common causes of neoplastic meningitis include primary intracerebral malignancies (glioblastoma multiforme, anaplastic astrocytoma, medulloblastoma) and metastatic disease (breast cancer, lung cancer, melanoma, lymphoma, leukemia).[1]
Causes
- Primary intracerebral malignancies that may cause metastases (drop-metastasis) to the subarachnoid space include:[1]
- Glioblastoma multiforme
- Anaplastic astrocytoma
- Medulloblastoma
- Supratentorial primitive neuroectodermal tumors (sPNET)
- Ependymoma
- Germinoma
- Choroid plexus carcinoma
- Vast majority of leptomeningeal metastases originates from a widespread metastatic disease (hematogenous spread). Common primary sites include:[1]
- Breast cancer (most common)
- Lung cancer
- Melanoma
- Lymphoma and leukemia
- Sarcomas rarely metastasizes to the meninges.
References
- ↑ 1.0 1.1 1.2 Pathology of leptomeningeal metastases. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningeal-metastases. Accessed on January 19, 2016