Sandbox:Ascites DD

Genes

TMEM67 TTC21B WDR19 ZNF423 CEP164 ANKS6 INPP5E TMEM216 AHI1 NPHP1 CEP290 RPGRIP1L ARL13B CC2D2A OFD1 TTC21B KIF7 TCTN1 CEP41 TMEM138 C5orf42 TCTN3 ZNF423 TMEM231 TCTN2 BBS1 BBS2 ARL6 BBS4 BBS5 MKKS BBS7 TTC8 BBS9 BBS10 TRIM32 BBS12 MKS1 CEP290 MKS1 CC2D2A NPHP3 B9D1 B9D2 IFT122 EVC EVC2 IFT80 OFD1 PKD1 PKD2

Preferred Table

Diseases		History and Symptoms					Physical Examination					Laboratory Findings			Other Findings
		Fever	Icterus	Abdominal pain	Peripheral edema	Chest pain	Jugular vein distension	Hepatomegaly	Skin rash	Edema	Spider angiomata	Serum to ascites albumin gradient (SAAG)	Ascitic fluid: Exudative Vs Transudative Colour	CBC
Hepatic causes	Cirrhosis	-	+	-	-	-	+	-	-	-	+	≥1.1	Transudate Opalescent
	Budd chiari syndrome	-	+	-	-	-	-	+	-	-	+
	Acute liver failure	+	+	+/-	+	-	-	+	+/-	+	-
	Alcoholic hepatitis	-	-	-	-	-	-	+	-	-	-
GI causes	Whipple disease	+	-	+	-	-	-	-	-	-	-	<1.1
	Peritonitis	+	-	+	-	-	-	-	-	-	-	≥1.1 or <1.1	Exudate Turbid or cloudy
	Pancreatitis	+ (Severe pancreatitis)	-	-	-	-	-	-	+ (In rare cases)	-	-	<1.1			Amylase level >100 units/L in the ascitic fluid
Cardiac causes	CHF	-	-	-	+	+	+	+ (In Rt heart failure)	-	+	-	≥1.1
	Pericarditis	+	-	-	-	+	+	+	-	-	-	≥1.1
Renal cause	Nephrotic syndrome	-	-	-	+	-	-	-	-	+	-	<1.1
Other causes	Sarcoidosis	+	-	-	-	+	-	+	+	-	-
	SLE	+	-	-	-	-	-	-	+	-	-
	TB	+	-	-	-	+	-	-	+ (In Cutaneous TB)	-	-	≥1.1 or <1.1
	Hypothyroidism	-			+ (Myxedematous edema)		-	-	-	+ (Myxedematous edema)	-				Low TSH level
	Cancer	-					+/-	+/-	-		+/-	≥1.1			Tumor markers for determination of the cancer type