Stomach cancer causes

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Stomach cancer causes

• Causes of stomach cancer depends on type of cancer.
• Adenocarcinomas are caused by genetic modulations due to chronic inflammation mainly by H. pylori bacteria.
• K-ras mutations oncogenes are found in invasive cancers and intestinal metaplasia.
• Hepatocyte growth factor receptor c-met oncogene is found in intestinal-type gastric cancers.
• Almost 50% of gastric cancers have alterations in genes TP53, TP73, APC, TFF, DCC, LOH, and FHIT.
• Inactivation of p53 in gastric epithelial cells reduce their ability to undergo apoptosis.