Lactose intolerance other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

Lactose intolerance test may be helpful in the diagnosis of lactose intolerance. Findings suggestive of lactose intolerance include bloating, diarrhea and abdominal pain and rising of blood glucose by less than 20 mg/dL after ingestion of lactose. Genetic test can also be used for diagnosis of primary lactase deficiency that is associated with CC genotype at -13.9 kb upstream of the lactase gene.

Other Diagnostic Studies

• Other diagnostic studies for lactose intolerance include:
  • Lactose intolerance test:
    • 50 gr of oral lactose in adults ( 2 g/kg in children) is administerd and blood glucose levels are checked at 0, 60, and 120 minutes after ingestion of glucose.
      • Presentation of symptoms such as bloating, diarrhea and abdominal pain and rising of blood glucose by less than 20 mg/dL (1.1 mmol/L) are diagnostic for lactose intolerance.
      • This test is used less than lactose breath hydrogen test because it needs repeated measurements of blood glucose level
    •  False negative results:
      • Diabetes
      • Bacterial overgrowth
  • Genetic test for primary lactase deficiency 
    • Acquired primary lactase deficiency is associated with a CC genotype at -13.9 kb upstream of the lactase gene and lactase persistence is related to TT genotype.