Chronic pancreatitis overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Chronic pancreatitis is a long-standing inflammatory disease of the pancreas characterized by irreversible change to pancreatic structure and function related to inflammation and fibrosis. Pancreatitis presents as a complex of pain and poor quality of life and, as it advances, develops symptoms related to exocrine and endocrine insufficiency, manifesting as malabsorption or diabetes.
Historical Perspective
The concept of pancreas and pancreatic duct was first described by Johannes Wirsung of Padua in 1642. In 1761, Giovanni Morgagni described the clinical syndrome of severe upper abdominal pain, vomiting, and collapse (acute pancreatitis). He is also credited with the earliest pathological recognition of cancer of the pancreas. In 1948, Eliason and Welty described distal pancreatectomy (DP). In 1980, Beger described duodenal-preserving pancreatic head resection (DPPHR) technique for chronic pancreatitis to decrease the morbidity of pancreatic head resection.
Classification
Chronic pancreatitis may be divided based on underlying morphology into large-duct type or small-duct type with or without calcification. The classification systems that have been used up til now for chronic pancreatitis may include ; Marseille, Marseille-Rome, Cambridge, TIGAR-O, ABC grading system and Manchester system.
Pathophysiology
Causes
Differentiating Chronic pancreatitis overview from Other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Natural History
Complications
Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Surgery for Chronic Pancreatitis tends to be divided into two areas - resectional and drainage procedures.[1]
Prevention
References
- ↑ Society for Surgery of the Alimentary Tract (SSAT) (2004). "Operative treatment for chronic pancreatitis". Retrieved 2007-06-09.