Portal vein thrombosis causes
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Portal vein thrombosis Microchapters |
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Portal vein thrombosis causes On the Web |
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Risk calculators and risk factors for Portal vein thrombosis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
Disease name] may be caused by [cause1], [cause2], or [cause3].
OR
Common causes of [disease] include [cause1], [cause2], and [cause3].
OR
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
OR
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
Causes
Life-threatening Causes
- Life-threatening causes of portal vein thrombosis include hepatocellular carcinoma, Philadelphia-chromosome negative chronic myeloproliferative disorders (polycythemia vera, essential thrombocythemia, idiopathic myelofibrosis, unclassifiable myeloproliferative disorders).
Common Causes
Portal vein thrombosis may be caused by:[1][2][3][4][5][6][7][8][9][10][11]
- Inherited prothrombotic disorders
- Acquired thrombophilic disorders
- Primary myeloproliferative disorders
- Paroxysmal nocturnal hemoglobinemia
- Antiphospholipid syndrome
- Increased factor VIII levels
- Thrombin activatable fibrinolysis inhibitor gene (TAFI)
Less Common Causes
Less common causes of portal vein thrombosis include:[12][13][3][14][15]
- Acquired conditions
- Cirrhosis
- Hepatocellular carcinoma
- Behçet's syndrome
- Recent pregnancy or oral contraceptive use
- Abdominal inflammatory lesions including infection, pancreatitis, and inflammatory bowel disease
- Trauma
- Philadelphia-chromosome negative chronic myeloproliferative disorders (polycythemia vera, essential thrombocythemia, idiopathic myelofibrosis, unclassifiable myeloproliferative disorders)
- Procedures
- Abdominal surgery or surgical injury of the portal vein axis
- Endoscopic sclerotherapy
- Transjugular intrahepatic portosystemic shunt
- Splenectomy
- Hepatic resection
- Pancreatic islet cell transplantation
Genetic Causes
- [Disease name] is caused by a mutation in the [gene name] gene.
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Oral contraceptive use |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | Cirrhosis, hepatocellular carcinoma, hepatic resection |
| Genetic | No underlying causes |
| Hematologic | Factor V Leiden mutation, factor II gene mutation, protein C deficiency, protein S deficiency, antithrombin III deficiency, primary myeloproliferative disorders, paroxysmal nocturnal hemoglobinemia, antiphospholipid syndrome, increased factor VIII levels, thrombin activatable fibrinolysis inhibitor gene (TAFI), Philadelphia-chromosome negative chronic myeloproliferative disorders (polycythemia vera, essential thrombocythemia, idiopathic myelofibrosis, unclassifiable myeloproliferative disorders) |
| Iatrogenic | Abdominal surgery or surgical injury of the portal vein axis, transjugular intrahepatic portosystemic shunt, abdominal inflammatory lesions including infection, pancreatitis, and inflammatory bowel disease, trauma, procedures, endoscopic sclerotherapy, splenectomy, pancreatic islet cell transplantation |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | Recent pregnancy |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
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3References
- ↑ Amitrano L, Guardascione MA, Brancaccio V, Margaglione M, Manguso F, Iannaccone L, Grandone E, Balzano A (2004). "Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis". J. Hepatol. 40 (5): 736–41. doi:10.1016/j.jhep.2004.01.001. PMID 15094219.
- ↑ Janssen HL, Meinardi JR, Vleggaar FP, van Uum SH, Haagsma EB, van Der Meer FJ, van Hattum J, Chamuleau RA, Adang RP, Vandenbroucke JP, van Hoek B, Rosendaal FR (2000). "Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study". Blood. 96 (7): 2364–8. PMID 11001884.
- ↑ 3.0 3.1 Primignani M, Martinelli I, Bucciarelli P, Battaglioli T, Reati R, Fabris F, Dell'era A, Pappalardo E, Mannucci PM (2005). "Risk factors for thrombophilia in extrahepatic portal vein obstruction". Hepatology. 41 (3): 603–8. doi:10.1002/hep.20591. PMID 15726653.
- ↑ Denninger MH, Chaït Y, Casadevall N, Hillaire S, Guillin MC, Bezeaud A, Erlinger S, Briere J, Valla D (2000). "Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors". Hepatology. 31 (3): 587–91. doi:10.1002/hep.510310307. PMID 10706547.
- ↑ Primignani M, Barosi G, Bergamaschi G, Gianelli U, Fabris F, Reati R, Dell'Era A, Bucciarelli P, Mannucci PM (2006). "Role of the JAK2 mutation in the diagnosis of chronic myeloproliferative disorders in splanchnic vein thrombosis". Hepatology. 44 (6): 1528–34. doi:10.1002/hep.21435. PMID 17133457.
- ↑ Sekhar M, McVinnie K, Burroughs AK (2013). "Splanchnic vein thrombosis in myeloproliferative neoplasms". Br. J. Haematol. 162 (6): 730–47. doi:10.1111/bjh.12461. PMID 23855810.
- ↑ Janssen HL, Wijnhoud A, Haagsma EB, van Uum SH, van Nieuwkerk CM, Adang RP, Chamuleau RA, van Hattum J, Vleggaar FP, Hansen BE, Rosendaal FR, van Hoek B (2001). "Extrahepatic portal vein thrombosis: aetiology and determinants of survival". Gut. 49 (5): 720–4. PMC 1728504. PMID 11600478.
- ↑ Bergamaschi GM, Primignani M, Barosi G, Fabris FM, Villani L, Reati R, Dell'era A, Mannucci PM (2008). "MPL and JAK2 exon 12 mutations in patients with the Budd-Chiari syndrome or extrahepatic portal vein obstruction". Blood. 111 (8): 4418. doi:10.1182/blood-2008-02-137687. PMID 18398061.
- ↑ Romano F, Caprotti R, Scaini A, Conti M, Scotti M, Colombo G, Uggeri F (2006). "Elective laparoscopic splenectomy and thrombosis of the spleno-portal axis: a prospective study with ecocolordoppler ultrasound". Surg Laparosc Endosc Percutan Tech. 16 (1): 4–7. doi:10.1097/01.sle.0000202187.80407.09. PMID 16552370.
- ↑ Yoshiya S, Shirabe K, Nakagawara H, Soejima Y, Yoshizumi T, Ikegami T, Yamashita Y, Harimoto N, Nishie A, Yamanaka T, Maehara Y (2014). "Portal vein thrombosis after hepatectomy". World J Surg. 38 (6): 1491–7. doi:10.1007/s00268-013-2440-8. PMID 24407940.
- ↑ White SA, London NJ, Johnson PR, Davies JE, Pollard C, Contractor HH, Hughes DP, Robertson GS, Musto PP, Dennison AR (2000). "The risks of total pancreatectomy and splenic islet autotransplantation". Cell Transplant. 9 (1): 19–24. PMID 10784062.
- ↑ Qi X, Ren W, De Stefano V, Fan D (2014). "Associations of coagulation factor V Leiden and prothrombin G20210A mutations with Budd-Chiari syndrome and portal vein thrombosis: a systematic review and meta-analysis". Clin. Gastroenterol. Hepatol. 12 (11): 1801–12.e7. doi:10.1016/j.cgh.2014.04.026. PMID 24793031.
- ↑ Koshy A, Jeyakumari M (2007). "High FVIII level is associated with idiopathic portal vein thrombosis in South India". Am. J. Med. 120 (6): 552.e9–11. doi:10.1016/j.amjmed.2006.02.016. PMID 17524760.
- ↑ Chamouard P, Pencreach E, Maloisel F, Grunebaum L, Ardizzone JF, Meyer A, Gaub MP, Goetz J, Baumann R, Uring-Lambert B, Levy S, Dufour P, Hauptmann G, Oudet P (1999). "Frequent factor II G20210A mutation in idiopathic portal vein thrombosis". Gastroenterology. 116 (1): 144–8. PMID 9869612.
- ↑ Dentali F, Galli M, Gianni M, Ageno W (2008). "Inherited thrombophilic abnormalities and risk of portal vein thrombosis. a meta-analysis". Thromb. Haemost. 99 (4): 675–82. doi:10.1160/TH07-08-0526. PMID 18392325.