Sandbox:ajay

Lab

There are 3 main ways in which food allergies can be detected in EE. – Skin prick testing – Blood allergy testing (eg. RAST) – Atopy patch testing

Complications

• The complications of the EoE are as follows:
• Scarring of esophagus-leading to dysphagia
• Esophageal stenosis- causing food stuck
• Tears or perforation during the endoscopy or retching leading to Boar-heave syndrome.

Medical therapy

Treatment Advantages Disadvantages Medications Topical steroids (fluticasone, budesonide) Ease of administration.High degree of efficacy in randomized controlled trials. Candidiasis, Recurrent disease activity after cessation of topical steroids Systemic steroids High degree of effectiveness.Ease of administration Toxicities of systemic steroidRecurrent disease after cessation Antihistamines Ease of administration Limited data to support effectiveness Leukotriene antagonist Symptom improvement in uncontrolled studies Higher doses may be needed for effectNo change in esophageal eosinophiliaSide effects of nausea and myalgias Immunomodulator (azathioprine, 6 mercaptopurine) Steroid sparing agent ImmunosuppressionSide effect profileLimited data (3 patients) to support use Anti-TNF therapy (infliximab) Rationale based on increased tissue expression of TNF No clinical improvement in a small uncontrolled trial Anti-IL-5 therapy Rationale based on role of IL-5 in systemic eosinophilic disorders Conflicting data to support efficacy Cromolyn sodium Rationale based on asthma model Limited pediatric data does not support effectiveness Diet Elemental High degree of effectivenessSimplified initial formula dietAvoidance of long-term use of medications Poor palatabilityRequires prolonged period of foodReintroductionNeed for repeated EGD and biopsies to identify allergen Directed elimination High degree of effectivenessTheoretical advantage of more selective dietAvoidance of long-term use of medications Skin prick test with poor predictive valueAtopy patch testing not standardizedNeed for repeated EGD and biopsies to identify allergen Empiric elimination High degree of effectivenessAvoidance of long-term use of medications Need for repeated EGD and biopsy to identify allergenHigh degree of vigilance to avoid contamination Dilation High degree of effectivenessProlonged symptom response without medications Reports of esophageal laceration causing significant painReports of esophageal perforation and hospitalization