Autoimmune pancreatitis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Pathophysiology
Pathogenesis
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- Microscopic findings suggestive of autoimmune pancreatitis may include:[1]
Type 1 AIP:
- A lymphoplasmacytic sclerosing pancreatitis
- >10 IgG4-positive cells with at least two of the following
- Periductal lymphoplasmacytic infiltrate
- Obliterative phlebitis
- Acinar fibrosis
Type 2 AIP or Idiopathic duct-centric pancreatitis (IDCP):
- Pancreatic duct: Granulocytic epithelial lesion
- Pancreatic parenchyma: Minimal IgG4-positive cells
References
- ↑ Chari ST, Takahashi N, Levy MJ, Smyrk TC, Clain JE, Pearson RK, Petersen BT, Topazian MA, Vege SS (2009). "A diagnostic strategy to distinguish autoimmune pancreatitis from pancreatic cancer". Clin. Gastroenterol. Hepatol. 7 (10): 1097–103. doi:10.1016/j.cgh.2009.04.020. PMID 19410017.