S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12gene.[1][2] It is also known as calgranulin C.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.[2]
References
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Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID7759097.
Marti T, Erttmann KD, Gallin MY (1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin". Biochem. Biophys. Res. Commun. 221 (2): 454–8. doi:10.1006/bbrc.1996.0616. PMID8619876.
Ilg EC, Troxler H, Bürgisser DM, et al. (1996). "Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry". Biochem. Biophys. Res. Commun. 225 (1): 146–50. doi:10.1006/bbrc.1996.1144. PMID8769108.
Hofmann MA, Drury S, Fu C, et al. (1999). "RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides". Cell. 97 (7): 889–901. doi:10.1016/S0092-8674(00)80801-6. PMID10399917.
Moroz OV, Antson AA, Dodson GG, et al. (2000). "Crystallization and preliminary X-ray diffraction analysis of human calcium-binding protein S100A12". Acta Crystallogr. D. 56 (Pt 2): 189–91. doi:10.1107/S0907444999014936. PMID10666601.
Moroz OV, Antson AA, Murshudov GN, et al. (2001). "The three-dimensional structure of human S100A12". Acta Crystallogr. D. 57 (Pt 1): 20–9. doi:10.1107/S090744490001458X. PMID11134923.
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Moroz OV, Antson AA, Dodson EJ, et al. (2002). "The structure of S100A12 in a hexameric form and its proposed role in receptor signalling". Acta Crystallogr. D. 58 (Pt 3): 407–13. doi:10.1107/S0907444901021278. PMID11856825.
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Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". J. Biol. Chem. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID12042313.
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