Ficolin-3 is a protein that in humans is encoded by the FCN3gene. Ficolin-3 was initially identified as H-ficolin, in which H is after the Hakata antigen that was previously found as an autoantigen in patients who lived in the city of Hakata.[1][2][3]
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.[3]
References
↑Sugimoto R, Yae Y, Akaiwa M, Kitajima S, Shibata Y, Sato H, Hirata J, Okochi K, Izuhara K, Hamasaki N (Sep 1998). "Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family". J Biol Chem. 273 (33): 20721–7. doi:10.1074/jbc.273.33.20721. PMID9694814.
↑Akaiwa M, Yae Y, Sugimoto R, Suzuki SO, Iwaki T, Izuhara K, Hamasaki N (Jun 1999). "Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile". J Histochem Cytochem. 47 (6): 777–86. doi:10.1177/002215549904700607. PMID10330454.
Yae Y, Inaba S, Sato H (1991). "Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus". Biochim. Biophys. Acta. 1078 (3): 369–76. doi:10.1016/0167-4838(91)90158-v. PMID1859827.
Inaba S, Okochi K, Yae Y (1991). "Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system". Fukuoka Igaku Zasshi. 81 (9): 284–91. PMID2276712.
Matsushita M, Kuraya M, Hamasaki N (2002). "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)". J. Immunol. 168 (7): 3502–6. doi:10.4049/jimmunol.168.7.3502. PMID11907111.
Tsujimura M, Miyazaki T, Kojima E (2003). "Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth". Clin. Chim. Acta. 325 (1–2): 139–46. doi:10.1016/S0009-8981(02)00274-7. PMID12367778.
Zeng L, Dai J, Ying K (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID12624729.
Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Anderson NL, Polanski M, Pieper R (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID14718574.
Otsuki T, Ota T, Nishikawa T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.
Muzny DM, Scherer SE, Kaul R (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. doi:10.1038/nature04728. PMID16641997.
