Aldehyde dehydrogenase 9 family, member A1

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.

External links

• Human ALDH9A1 genome location and ALDH9A1 gene details page in the UCSC Genome Browser.

Further reading

• Kurys G, Ambroziak W, Pietruszko R (1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde". J. Biol. Chem. 264 (8): 4715–21. PMID 2925663.
• Kurys G, Shah PC, Kikonygo A, et al. (1994). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde". Eur. J. Biochem. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919.
• Kikonyogo A, Pietruszko R (1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution". Biochem. J. 316 (1): 317–24. PMC 1217341. PMID 8645224.
• Izaguirre G, Kikonyogo A, Pietruszko R (1998). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 118 (1): 59–64. doi:10.1016/s0305-0491(97)00022-9. PMID 9417993.
• Vaz FM, Fouchier SW, Ofman R, et al. (2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis". J. Biol. Chem. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312.
• Izaguirre G, Pietruszko R, Cho S, MacKerell A (2002). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs". J. Biomol. Struct. Dyn. 19 (3): 429–47. doi:10.1080/07391102.2001.10506752. PMID 11790142.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.