Corepressor interacting with RBPJ 1 is a protein that in humans is encoded by the CIR1 gene .[1] [2] [3] [4]
Interactions CIR (gene) has been shown to interact with SNW1 .[5]
Model organisms Model organisms have been used in the study of CIR1 function. A conditional knockout mouse line called Cir1tm3a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute .[6] phenotypic screen [7] [8] [9] [10] [11] [12] [13]
Cir1 knockout mouse phenotype
Characteristic
Phenotype
All data available at.[7] [12] [13]
Peripheral blood leukocytes 6 Weeks
Normal
Insulin
Normal
Haematology Normal
Homozygous viability at P14
Abnormal
Recessive lethal studyAbnormal
Body weight
Normal
Neurological assessment
Normal
Grip strength
Normal
Dysmorphology Normal
Indirect calorimetry Normal
Glucose tolerance test Normal
Auditory brainstem response Normal
DEXA Normal
Radiography Normal
Eye morphology
Normal
Clinical chemistry Normal
Haematology Normal
Peripheral blood leukocytes 16 Weeks
Normal
Heart weight
Normal
Salmonella Normal
Cytotoxic T Cell Function
Normal
Spleen Immunophenotyping
Normal
Mesenteric Lymph Node Immunophenotyping
Normal
Bone Marrow Immunophenotyping
Normal
Epidermal Immune Composition
Normal
Influenza Challenge
Normal
References
↑ Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (Feb 2005). "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing". Experimental Cell Research . 303 (2): 375–87. doi :10.1016/j.yexcr.2004.10.012 . PMID 15652350 . ↑ Zhang J, Chen H, Weinmaster G, Hayward SD (Mar 2001). "Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC" . Journal of Virology . 75 (6): 2946–56. doi :10.1128/JVI.75.6.2946-2956.2001 . PMC 115921 PMID 11222720 . ↑ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex" . Proceedings of the National Academy of Sciences of the United States of America . 96 (1): 23–8. doi :10.1073/pnas.96.1.23 . PMC 15086 PMID 9874765 . ↑ "Entrez Gene: CIR CBF1 interacting corepressor" .↑ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters" . Journal of Virology . 74 (4): 1939–47. doi :10.1128/JVI.74.4.1939-1947.2000 . PMC 111672 PMID 10644367 . ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice" . Acta Ophthalmologica . 88 . doi :10.1111/j.1755-3768.2010.4142.x . ↑ 7.0 7.1 "International Mouse Phenotyping Consortium" .↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature . 474 (7351): 262–3. doi :10.1038/474262a . PMID 21677718 . ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 . PMID 17218247 . ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes" . Cell . 154 (2): 452–64. doi :10.1016/j.cell.2013.06.022 . PMC 3717207 PMID 23870131 . ↑ 12.0 12.1 "Infection and Immunity Immunophenotyping (3i) Consortium" .↑ 13.0 13.1 "OBCD Consortium" .
External links Further reading
DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP (Jan 1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system" . Molecular and Cellular Biology . 7 (1): 379–87. doi :10.1128/mcb.7.1.379 . PMC 365079 PMID 3031469 . Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters" . Journal of Virology . 74 (4): 1939–47. doi :10.1128/JVI.74.4.1939-1947.2000 . PMC 111672 PMID 10644367 . Krithivas A, Young DB, Liao G, Greene D, Hayward SD (Oct 2000). "Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells" . Journal of Virology . 74 (20): 9637–45. doi :10.1128/JVI.74.20.9637-9645.2000 . PMC 112396 PMID 11000236 . Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex" . Molecular and Cellular Biology . 21 (18): 6222–32. doi :10.1128/MCB.21.18.6222-6232.2001 . PMC 87339 PMID 11509665 . Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs" . Genome Research . 11 (10): 1758–65. doi :10.1101/gr.180101 . PMC 311163 PMID 11591653 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 .
