GC-rich sequence DNA-binding factor is a protein that in humans is encoded by the C2orf3gene.[1][2][3][4]
The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.[4]
References
↑Johnson AC, Kageyama R, Popescu NC, Pastan I (Feb 1992). "Expression and chromosomal localization of the gene for the human transcriptional repressor GCF". J Biol Chem. 267 (3): 1689–94. PMID1370479.
↑Kageyama R, Pastan I (Jan 1990). "Molecular cloning and characterization of a human DNA binding factor that represses transcription". Cell. 59 (5): 815–25. doi:10.1016/0092-8674(89)90605-3. PMID2556218.
↑Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, Massinen S, Onkamo P, Warnke A, Griesemann H, Hoffmann P, Nopola-Hemmi J, Lyytinen H, Schulte-Korne G, Kere J, Nothen MM, Peyrard-Janvid M (Apr 2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia". Hum Mol Genet. 16 (6): 667–77. doi:10.1093/hmg/ddm009. PMID17309879.
Mao P (1999). "[Revisions of the cDNA and primary protein structure of human transcription factor GCF]". Hokkaido Igaku Zasshi. 74 (4): 315–30. PMID10480038.
Takimoto M, Mao P, Wei G, et al. (1999). "Molecular analysis of the GCF gene identifies revisions to the cDNA and amino acid sequences(1)". Biochim. Biophys. Acta. 1447 (1): 125–31. doi:10.1016/S0167-4781(99)00127-X. PMID10500253.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID15815621.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.
