HNRNPLL

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.

Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008].

Further reading

• Lai, Y.; Song, M.; Hakala, K.; Weintraub, S. T.; Shiio, Y. (2011). "Proteomic Dissection of the von Hippel–Lindau (VHL) Interactome". Journal of Proteome Research. 10 (11): 5175–5182. doi:10.1021/pr200642c. PMC 3208728. PMID 21942715.
• Topp, J. D.; Jackson, J.; Melton, A. A.; Lynch, K. W. (2008). "A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4". RNA. 14 (10): 2038–2049. doi:10.1261/rna.1212008. PMC 2553740. PMID 18719244.
• Wu, Z.; Yates, A. L.; Hoyne, G. F.; Goodnow, C. C. (2010). "Consequences of Increased CD45RA and RC Isoforms for TCR Signaling and Peripheral T Cell Deficiency Resulting from Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation". The Journal of Immunology. 185 (1): 231–238. doi:10.4049/jimmunol.0903625. PMID 20505149.
• Oberdoerffer, S.; Moita, L. F.; Neems, D.; Freitas, R. P.; Hacohen, N.; Rao, A. (2008). "Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–691. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.
• Fedorova, O. A.; Moiseeva, T. N.; Nikiforov, A. A.; Tsimokha, A. S.; Livinskaya, V. A.; Hodson, M.; Bottrill, A.; Evteeva, I. N.; Ermolayeva, J. B.; Kuznetzova, I. M.; Turoverov, K. K.; Eperon, I.; Barlev, N. A. (2011). "Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism". Biochemical and Biophysical Research Communications. 416 (3–4): 258–265. doi:10.1016/j.bbrc.2011.10.126. PMID 22079093.
• Shur, I.; Ben-Avraham, D.; Benayahu, D. (2004). "Alternatively spliced isoforms of a novel stromal RNA regulating factor". Gene. 334: 113–121. doi:10.1016/j.gene.2004.03.012. PMID 15256261.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.