CD200R1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.

Further reading

• Matsue H (2006). "CD 200-mediated regulation of skin immunity". J. Invest. Dermatol. 125 (6): x–xi. doi:10.1111/j.0022-202X.2005.23978.x. PMID 16354172.
• Shiratori I, Yamaguchi M, Suzukawa M, et al. (2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". J. Immunol. 175 (7): 4441–9. doi:10.4049/jimmunol.175.7.4441. PMID 16177086.
• Cherwinski HM, Murphy CA, Joyce BL, et al. (2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function". J. Immunol. 174 (3): 1348–56. doi:10.4049/jimmunol.174.3.1348. PMID 15661892.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Foster-Cuevas M, Wright GJ, Puklavec MJ, et al. (2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor". J. Virol. 78 (14): 7667–76. doi:10.1128/JVI.78.14.7667-7676.2004. PMC 434103. PMID 15220441.
• Karteris E, Chen J, Randeva HS (2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system". J. Clin. Endocrinol. Metab. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID 15070969.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Wright GJ, Cherwinski H, Foster-Cuevas M, et al. (2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200". J. Immunol. 171 (6): 3034–46. doi:10.4049/jimmunol.171.6.3034. PMID 12960329.
• Vieites JM, de la Torre R, Ortega MA, et al. (2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13". Gene. 311: 99–104. doi:10.1016/S0378-1119(03)00562-6. PMID 12853143.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• CD200R1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CD200R1 genome location and CD200R1 gene details page in the UCSC Genome Browser.
• Human HCRTR2 genome location and HCRTR2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.