Lipase member H is an enzyme that in humans is encoded by the LIPHgene.[1][2][3]
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.[3]
References
↑Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (Sep 2002). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine". Genomics. 80 (3): 268–73. doi:10.1006/geno.2002.6837. PMID12213196.
↑Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H (Sep 2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid". J Biol Chem. 277 (37): 34254–63. doi:10.1074/jbc.M201659200. PMID12063250.
Wen XY, Hegele RA, Wang J, et al. (2004). "Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans". Hum. Mol. Genet. 12 (10): 1131–43. doi:10.1093/hmg/ddg124. PMID12719377.
Hiramatsu T, Sonoda H, Takanezawa Y, et al. (2004). "Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta". J. Biol. Chem. 278 (49): 49438–47. doi:10.1074/jbc.M213018200. PMID12963729.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Kazantseva A, Goltsov A, Zinchenko R, et al. (2006). "Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH". Science. 314 (5801): 982–5. doi:10.1126/science.1133276. PMID17095700.
Ali G, Chishti MS, Raza SI, et al. (2007). "A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis". Hum. Genet. 121 (3–4): 319–25. doi:10.1007/s00439-007-0344-0. PMID17333281.
