Neuron-specific vesicular protein calcyon is a protein that in humans is encoded by the CALYgene.[1][2][3] Its alternative name is Calcyon.
The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with dopamine receptor D1 and may interact with other DA receptor subtypes and/or GPCRs.[3]
References
↑Lezcano N, Mrzljak L, Eubanks S, Levenson R, Goldman-Rakic P, Bergson C (Mar 2000). "Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein". Science. 287 (5458): 1660–4. doi:10.1126/science.287.5458.1660. PMID10698743. (Retracted. If this is an intentional citation to a retracted paper, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
Ali MK, Bergson C (2004). "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane". J. Biol. Chem. 278 (51): 51654–63. doi:10.1074/jbc.M305803200. PMID14534309.
Luo X, Kranzler H, Lappalainen J, et al. (2005). "CALCYON gene variation, schizophrenia, and cocaine dependence". Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 25–30. doi:10.1002/ajmg.b.20092. PMID14755439.
Laurin N, Misener VL, Crosbie J, et al. (2006). "Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder". Mol. Psychiatry. 10 (12): 1117–25. doi:10.1038/sj.mp.4001737. PMID16172615.
Xiao J, Dai R, Negyessy L, Bergson C (2006). "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis". J. Biol. Chem. 281 (22): 15182–93. doi:10.1074/jbc.M600265200. PMID16595675.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.
Kruusmägi M, Zelenin S, Brismar H, Scott L (2007). "Intracellular dynamics of calcyon, a neuron-specific vesicular protein". NeuroReport. 18 (15): 1547–51. doi:10.1097/WNR.0b013e3282f03f51. PMID17885599.
