C1QTNF5

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

C1q and tumor necrosis factor related protein 5, also known as C1QTNF5, is a protein which in humans is encoded by the C1QTNF5 gene.

Function

The CTRP5 protein is a member of the C1q / tumor necrosis factor superfamily, which shows diverse functions including cell adhesion and as components of the basement membrane. C1QTNF5 is mutant in late-onset retinal degeneration.

External links

• Human C1QTNF5 genome location and C1QTNF5 gene details page in the UCSC Genome Browser.

Further reading

• Shapiro L, Scherer PE (1998). "The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor". Curr. Biol. 8 (6): 335–8. doi:10.1016/S0960-9822(98)70133-2. PMID 9512423.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hayward C, Shu X, Cideciyan AV, et al. (2004). "Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration". Hum. Mol. Genet. 12 (20): 2657–67. doi:10.1093/hmg/ddg289. PMID 12944416.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ayyagari R, Mandal MN, Karoukis AJ, et al. (2005). "Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutation". Invest. Ophthalmol. Vis. Sci. 46 (9): 3363–71. doi:10.1167/iovs.05-0159. PMID 16123441.
• Subrayan V, Morris B, Armbrecht AM, et al. (2006). "Long anterior lens zonules in late-onset retinal degeneration (L-ORD)". Am. J. Ophthalmol. 140 (6): 1127–9. doi:10.1016/j.ajo.2005.06.023. PMID 16376663.
• Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
• Shu X, Tulloch B, Lennon A, et al. (2006). "Disease mechanisms in late-onset retinal macular degeneration associated with mutation in C1QTNF5". Hum. Mol. Genet. 15 (10): 1680–9. doi:10.1093/hmg/ddl091. PMID 16600989.
• Shu X, Tulloch B, Lennon A, et al. (2007). "Biochemical characterisation of the C1QTNF5 gene associated with late-onset retinal degeneration. A genetic model of age-related macular degeneration". Adv. Exp. Med. Biol. 572: 41–8. doi:10.1007/0-387-32442-9_7. PMID 17249553.