Complement component 1s
| complement component 1, s subcomponent | |
|---|---|
| Identifiers | |
| Symbol | C1S |
| Entrez | 716 |
| HUGO | 1247 |
| OMIM | 120580 |
| RefSeq | NM_001734 |
| UniProt | P09871 |
| Other data | |
| EC number | 3.4.21.42 |
| Locus | Chr. 12 p13 |
Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r ) is a protein involved in the complement system.[1][2][3][4]
C1s cleaves C4, which eventually leads to the production of the C4b-C2a form of C3-convertase.
References
- ↑ Sim, R.B. (1981). "The human complement system serine proteases C1r and C1s and their proenzymes". Methods Enzymol. 80: 26–42. doi:10.1016/s0076-6879(81)80006-7. PMID 6281620.
- ↑ MacKinnon, C.M.; Carter, P.E.; Smyth, S.J.; Dunbar, B.; Fothergill, J.E. (1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". Eur. J. Biochem. 169: 547–553. doi:10.1111/j.1432-1033.1987.tb13644.x. PMID 3500856.
- ↑ Müller-Eberhard, H.J. (1988). "Molecular organization and function of the complement system". Annu. Rev. Biochem. 57: 321–347. doi:10.1146/annurev.bi.57.070188.001541. PMID 3052276.
- ↑ Skoog, M.T.; Mehdi, S.; Wiseman, J.S.; Bey, P. (1989). "The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochim. Biophys. Acta. 996 (1–2): 89–94. doi:10.1016/0167-4838(89)90099-x. PMID 2500154.
External links
- Complement+C1s at the US National Library of Medicine Medical Subject Headings (MeSH)
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