KCNRG

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Potassium channel regulator, also known as KCNRG, is a protein which in humans is encoded by theKCNRG gene.

Function

KCNRG is a soluble protein with characteristics suggesting it forms hetero-tetramers with voltage-gated K⁺ channels and inhibits their function.

Clinical significance

KCNRG has been found to be predominantly expressed in lung tissue. Additionally, KCNRG transcripts are also found in liver and some other tissues, but in lower extent. Researchers at Uppsala University have found that KCNRG is found in the lower lung and constitutes an autoantigen in a rare disorder named autoimmune polyendocrine syndrome type 1 (APS1). As a subset of patients with APS1 suffer from respiratory disease, an autoimmune reaction against KCNRG may explain the respiratory disease in these patients. KCNRG may also be connected to common nonfatal diseases like asthma and chronic bronchitis.

Further reading

• Cho YG, Kim CJ, Song JH, et al. (2006). "Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas". Exp. Mol. Med. 38 (3): 247–55. doi:10.1038/emm.2006.30. PMID 16819283.
• Skoblov M, Shakhbazov K, Oshchepkov D, et al. (2006). "Human RFP2 gene promoter: Unique structure and unusual strength". Biochem. Biophys. Res. Commun. 342 (3): 859–66. doi:10.1016/j.bbrc.2006.01.187. PMC 1994241. PMID 16499869.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Corcoran MM, Hammarsund M, Zhu C, et al. (2004). "DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse". Genes Chromosomes Cancer. 40 (4): 285–97. doi:10.1002/gcc.20046. PMID 15188451.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ivanov DV, Tyazhelova TV, Lemonnier L, et al. (2003). "A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3". FEBS Lett. 539 (1–3): 156–60. doi:10.1016/S0014-5793(03)00211-4. PMID 12650944.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.