Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYRgene.[1][2][3][4]
To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.[4]
References
↑Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC (Jan 2002). "CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation". Dev Biol. 242 (2): 236–54. doi:10.1006/dbio.2001.0527. PMID11820818.
↑Luo C, Xiao X, Liu D, Chen S, Li M, Xu A, Liu J, Gao S, Wu S, He D (Feb 2007). "CABYR is a novel cancer-testis antigen in lung cancer". Clin Cancer Res. 13 (4): 1288–97. doi:10.1158/1078-0432.CCR-06-1742. PMID17317841.
↑Kim YH, Jha KN, Mandal A, Vanage G, Farris E, Snow PL, Klotz K, Naaby-Hansen S, Flickinger CJ, Herr JC (Oct 2005). "Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A". Dev Biol. 286 (1): 46–56. doi:10.1016/j.ydbio.2005.07.005. PMID16139264.
Visconti PE, Westbrook VA, Chertihin O, et al. (2002). "Novel signaling pathways involved in sperm acquisition of fertilizing capacity". J. Reprod. Immunol. 53 (1–2): 133–50. doi:10.1016/S0165-0378(01)00103-6. PMID11730911.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Ficarro S, Chertihin O, Westbrook VA, et al. (2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". J. Biol. Chem. 278 (13): 11579–89. doi:10.1074/jbc.M202325200. PMID12509440.
Hsu HC, Lee YL, Cheng TS, et al. (2005). "Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain". Biochem. Biophys. Res. Commun. 329 (3): 1108–17. doi:10.1016/j.bbrc.2005.02.089. PMID15752768.
