INSM1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.

Interactions

INSM1 has been shown to interact with SORBS1.

Further reading

• Goto Y, De Silva MG, Toscani A, et al. (1992). "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs". J. Biol. Chem. 267 (21): 15252–7. PMID 1634555.
• Li Q, Notkins AL, Lan MS (1997). "Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1". Biochem. Biophys. Res. Commun. 236 (3): 776–81. doi:10.1006/bbrc.1997.7054. PMID 9245732.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Breslin MB, Zhu M, Notkins AL, Lan MS (2002). "Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence". Nucleic Acids Res. 30 (4): 1038–45. doi:10.1093/nar/30.4.1038. PMC 100352. PMID 11842116.
• Zhu M, Breslin MB, Lan MS (2002). "Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells". Pancreas. 24 (2): 139–45. doi:10.1097/00006676-200203000-00004. PMID 11854618.
• Xie J, Cai T, Zhang H, et al. (2003). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics. 80 (1): 54–61. doi:10.1006/geno.2002.6800. PMC 1237014. PMID 12079283.
• Breslin MB, Zhu M, Lan MS (2003). "NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system". J. Biol. Chem. 278 (40): 38991–7. doi:10.1074/jbc.M306795200. PMC 1236987. PMID 12890672.
• Tao Zhang; Breslin MB; Lan MS (2009). "Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest". J. Biol. Chem. 284 (9): 5574–81. doi:10.1074/jbc.M808843200. PMC 2645817. PMID 19124461.