High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8Bgene.[1][2]
References
↑Hayashi M, Matsushima K, Ohashi H, Tsunoda H, Murase S, Kawarada Y, Tanaka T (Nov 1998). "Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase". Biochem Biophys Res Commun. 250 (3): 751–6. doi:10.1006/bbrc.1998.9379. PMID9784418.
Persani L, Borgato S, Lania A, et al. (2001). "Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations". J. Clin. Endocrinol. Metab. 86 (8): 3795–800. doi:10.1210/jc.86.8.3795. PMID11502813.
Hayashi M, Shimada Y, Nishimura Y, et al. (2002). "Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene". Biochem. Biophys. Res. Commun. 297 (5): 1253–8. doi:10.1016/S0006-291X(02)02371-9. PMID12372422.
Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–74. doi:10.1016/S0898-6568(02)00146-8. PMID12681444.
Pérez-Torres S, Cortés R, Tolnay M, et al. (2003). "Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization". Exp. Neurol. 182 (2): 322–34. doi:10.1016/S0014-4886(03)00042-6. PMID12895443.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID15144186.