Helicase SKI2W is an enzyme that in humans is encoded by the SKIV2Lgene.[1][2][3]
Function
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex.[3]
References
↑Lee SG, Lee I, Park SH, Kang C, Song K (February 1995). "Identification and characterization of a human cDNA homologous to yeast SKI2". Genomics. 25 (3): 660–6. doi:10.1016/0888-7543(95)80008-A. PMID7759100.
↑Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (November 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID9799600.
Yang Z, Qu X, Yu CY (August 2001). "Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region". Frontiers in Bioscience. 6: D927–35. doi:10.2741/Yang. PMID11487501.
Shen L, Wu LC, Sanlioglu S, Chen R, Mendoza AR, Dangel AW, Carroll MC, Zipf WB, Yu CY (March 1994). "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication". The Journal of Biological Chemistry. 269 (11): 8466–76. PMID8132574.
Albertella MR, Jones H, Thomson W, Olavesen MG, Campbell RD (September 1996). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B)". Genomics. 36 (2): 240–51. doi:10.1006/geno.1996.0459. PMID8812450.
Lee SG, Song K (June 1997). "Genomic organization of the human DDX13 gene located between RD and RP1 in the class III MHC complex". Molecules and Cells. 7 (3): 414–8. PMID9264031.
Lee SG, Song K (February 2000). "Identification and characterization of a bidirectional promoter from the intergenic region between the human DDX13 and RD genes". Molecules and Cells. 10 (1): 47–53. doi:10.1007/s10059-000-0047-z. PMID10774746.
Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (November 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID11719186.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID17081983.
