FAM135B is located on the long arm of Chromosome 8 in humans on the anti-sense located at 24.23.[1] The following genes are near FAM135B on the chromosome:
COL22A1: Collagen producing gene that is a cell adhesion ligand for skin epithelial cells and fibroblast
KCNK9: Gene that encodes for a two pore potassium channel
Expression
FAM135B is expressed in the brain, ear, eye, pancreas and testis.[2] Within the brain, expression is apparent within the motor nucleus of trigeminal[3] In addition, it is mainly expressed in normal health states, although it has shown moderate expression in glioma, non-neoplasima as well as expression in germ cell tumors.[2]
FAM135B has shown to interact with KAT5, a gene that encodes for a histone acetyltransferase[4] through yeast two-hybrid experimentation.
Protein
The protein encoded on FAM135 is 1406 amino acids long. The protein contains a region called DUF676, believed to be a putative serine esterase as well as two protein regions called DUF3657.[1]
↑Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID16169070.
