Dendrocyte expressed seven transmembrane protein

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Dendrocyte expressed seven transmembrane protein is a protein that in humans is encoded by the DCSTAMP gene.

Function

This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012].

Further reading

• Lee, K. Y.; Huang, S. M.; Li, S; Kim, J. M. (2009). "Identification of differentially expressed genes in papillary thyroid cancers". Yonsei Medical Journal. 50 (1): 60–7. doi:10.3349/ymj.2009.50.1.60. PMC 2649849. PMID 19259350.
• Sakai, H; Okafuji, I; Nishikomori, R; Abe, J; Izawa, K; Kambe, N; Yasumi, T; Nakahata, T; Heike, T (2012). "The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation". International Immunology. 24 (1): 5–15. doi:10.1093/intimm/dxr088. PMID 22058328.
• Eleveld-Trancikova, D; Triantis, V; Moulin, V; Looman, M. W.; Wijers, M; Fransen, J. A.; Lemckert, A. A.; Havenga, M. J.; Figdor, C. G.; Janssen, R. A.; Adema, G. J. (2005). "The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum". Journal of Leukocyte Biology. 77 (3): 337–43. doi:10.1189/jlb.0804441. PMID 15601667.
• Beauregard, M; Gagnon, E; Guay-Bélanger, S; Morissette, J; Brown, J. P.; Michou, L (2014). "Identification of rare genetic variants in novel loci associated with Paget's disease of bone". Human Genetics. 133 (6): 755–68. doi:10.1007/s00439-013-1409-x. PMID 24370779.
• Kim, H. Y.; Cho, S; Yu, J; Sung, S; Kim, H (2010). "Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT". BMB reports. 43 (8): 547–53. PMID 20797317.
• Eleveld-Trancikova, D; Sanecka, A; Van Hout-Kuijer, M. A.; Looman, M. W.; Hendriks, I. A.; Jansen, B. J.; Adema, G. J. (2010). "DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation". Molecular Immunology. 47 (11–12): 1963–73. doi:10.1016/j.molimm.2010.04.019. PMID 20546900.
• Zeng, Z; Zhang, C; Chen, J (2013). "Lentivirus-mediated RNA interference of DC-STAMP expression inhibits the fusion and resorptive activity of human osteoclasts". Journal of Bone and Mineral Metabolism. 31 (4): 409–16. doi:10.1007/s00774-013-0434-0. PMID 23525827.
• Hartgers, F. C.; Looman, M. W.; Van Der Woning, B; Merkx, G. F.; Figdor, C. G.; Adema, G. J. (2001). "Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene". Immunogenetics. 53 (2): 145–9. doi:10.1007/s002510100302. PMID 11345591.
• Chiu, Y. H.; Mensah, K. A.; Schwarz, E. M.; Ju, Y; Takahata, M; Feng, C; McMahon, L. A.; Hicks, D. G.; Panepento, B; Keng, P. C.; Ritchlin, C. T. (2012). "Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)". Journal of Bone and Mineral Research. 27 (1): 79–92. doi:10.1002/jbmr.531. PMC 3304467. PMID 21987375.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.