RING finger protein 38 is a protein that in humans is encoded by the RNF38gene.[1]
This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID14702039.
Eisenberg I, Hochner H, Levi T, et al. (2002). "Cloning and characterization of a novel human gene RNF38 encoding a conserved putative protein with a RING finger domain". Biochem. Biophys. Res. Commun. 294 (5): 1169–1176. doi:10.1016/S0006-291X(02)00584-3. PMID12074600.