XAGE1D

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
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Wikidata
View/Edit Human

G antigen family D member 2 is a protein that in humans is encoded by the XAGE1D gene.

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.

Further reading

• Brinkmann U, Vasmatzis G, Lee B, Pastan I (1999). "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database". Cancer Res. 59 (7): 1445–8. PMID 10197611.
• Liu XF, Helman LJ, Yeung C, et al. (2000). "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma". Cancer Res. 60 (17): 4752–5. PMID 10987281.
• Zendman AJ, van Kraats AA, den Hollander AI, et al. (2002). "Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis". Int. J. Cancer. 97 (2): 195–204. doi:10.1002/ijc.1584. PMID 11774264.
• Zendman AJ, Van Kraats AA, Weidle UH, et al. (2002). "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma". Int. J. Cancer. 99 (3): 361–9. doi:10.1002/ijc.10371. PMID 11992404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Egland KA, Kumar V, Duray P, Pastan I (2003). "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers". Mol. Cancer Ther. 1 (7): 441–50. PMID 12479262.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Lim JH, Kim SP, Gabrielson E, et al. (2005). "Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation". Int. J. Cancer. 116 (2): 200–6. doi:10.1002/ijc.21007. PMID 15800911.
• Nakagawa K, Noguchi Y, Uenaka A, et al. (2006). "XAGE-1 expression in non-small cell lung cancer and antibody response in patients". Clin. Cancer Res. 11 (15): 5496–503. doi:10.1158/1078-0432.CCR-05-0216. PMID 16061866.
• Sato S, Noguchi Y, Ohara N, et al. (2007). "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors". Cancer Immun. 7: 5. PMC 2935747. PMID 17335148.