Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.[1]
It is one of six armadillo repeats containing X-linked proteins (ARMCX1 , ARMCX2 , ARMCX3 , ARMCX4 , ARMCX5 , and ARMCX6 (this protein)).
The function of this protein is unknown at this time.
Protein sequence 1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE
41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA
81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN
121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL
161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE
201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK
241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS
301 FMSLFIRNGN REILLETPAP
Homology ARMCX6 is conserved in many eukaryotic organisms.
Orthologs
taxonomic name
common name
NCBI entry
Percentage of sequence similarity
Length (AAs)
comments
Homo sapiens
Human [3] 100%
300
armadillo repeat containing X-linked 6
Macaca mulatta
Rhesus monkey [4] 97.0%
300
PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1
Equus caballus
Horse [5] 90.0%
300
PREDICTED: similar to armadillo repeat containing, X-linked 6
Danio rerio
zebrafish [6] 84.0%
301
Similar to RIKEN cDNA 0610039K22
Mus musculus
House Mouse [7] 97.7%
393
armadillo repeat containing, X-linked 6 (H. sapiens)-like
Bos taurus
cow [8] 83.0%
301
armadillo repeat containing, X-linked 6
Mus musculus
Mouse [9] 82.0%
301
armadillo repeat containing, X-linked 6
Takifugu rubripes
Tetradontoidea [10] 66.0%
818
aryl hydrocarbon receptor 2C
Caenorhabditis elegans
C. elegans [11] 50.0%
332
Serpentine Receptor, class H family member (srh-216)
Saccharomyces cerevisiae
Yeast [12] 70.0%
910
Hul5p
Gallus gallus
Chicken [13] 52.0%
317
PREDICTED: hypothetical protein
Secondary Structure The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.[2] [3]
10 20 30 40
....*....|....*....|....*....|....*....|....*..
ARMCX6 231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277
1DW9_A 19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65
+ + ++ + + + + + + + + + + ++++
File:Asdadwgtfw3w.jpg Cyanase segment having identity with ARMCX6. Expression Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.[4] [5] [6]
References External links Further reading
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome" . Nature . 434 (7031): 325–37. doi :10.1038/nature03440 . PMC 2665286 PMID 15772651 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
